Crystallization and preliminary X-ray analysis of GAP 31: a protein which inhibits the life cycle of HIV-1
1994
Lee-Huang, S. | Kung, H. | Chen, H.C. | Huang, P.L. | Rybak, S.M. | Huang, P.L. | Bourinbaiar, A.S. | Musayev, F. | Liaw, Y.C.
GAP an anti-HIV plant protein that we have identified and purified to homogeneity from Gelonium multiflorum. It is the first reported example of an anti-HIV agent capable of acting against multiple stages of the viral life cycle, on viral infection and viral replication. GAP 31 is a unique paragon of multi-functional protein. In addition to anti-HIV activity, it also exhibits anti-tumor action, DNA binding, RNA binding and ribosome inactivation. The present crystals diffract up to 2.0 Angstrom resolution and belong to monoclinic space group P2(1). The cell dimensions are a = 49.30(2) Angstrom, b = 44-57(2) Angstrom, c = 137-78(7) Angstrom and P = 98.32(3) degrees. There are two molecules of molecular weight 31 kDa in an asymmetric unit with a solvent content of 49%.
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