Rapid decay of serum IgG recognizing gram-negative cell wall core antigens in neonatal calves

Douglas, V.L.; Cullor, J.S.; Tyler, J.W.; Thurmond, M.C.; Bushnell, R.B.

Rapid decay of serum IgG recognizing gram-negative cell wall core antigens in neonatal calves

1989

Douglas, V.L. | Cullor, J.S. | Tyler, J.W. | Thurmond, M.C. | Bushnell, R.B.

Serum immunoglobulins of the IgG isotype recognizing common gram-negative cell core epitopes were serially measured, using a direct ELISA, on samples obtained from 20 neonatal Holstein calves. An R-mutant Escherichia coli (strain J5) was used as a plate antigen in this assay. Total serum IgG concentration was measured using radial immunodiffusion. Half-lives of core antigen-specific IgG (7.56 days) and total serum IgG (22.66 days) were dramatically different (P less than 0.0005). This may be an indication of cross-reactive consumption of core antigen-specific immunoglobulins.

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