Heterogeneous associations of insoluble dietary fibre intake with subsequent glycosylated Hb levels among Chinese adults with type 2 diabetes: a quantile regression approach
2014
Tan, Ziwen | Ruan, Xiaonan | Chen, Yue | Jiang, Junyi | Zhou, Yi | Qiu, Hua | Qin, Guoyou | Xu, Wang Hong
Dietary fibre intake has been suggested to reduce blood glucose levels in diabetic patients, particularly when glycosylated Hb (HbA₁c) levels are high. In the present study, we used a quantile regression (QR) approach to characterise the possible heterogeneous associations of dietary fibre intake with HbA₁c levels in Chinese diabetic patients. A total of 497 diabetic patients participated in the baseline survey in 2006 and in the follow-up survey in 2011, both of which were conducted in Pudong New Area of Shanghai, China. Structured in-person interviews were conducted to collect information on demographic characteristics and lifestyle factors. Dietary intake was assessed using a validated FFQ. Blood samples were collected during the interviews for biochemical assays. QR models were used to examine the heterogeneous associations of dietary factors with HbA₁c levels. A significant marginal association of insoluble dietary fibre intake with subsequent HbA₁c levels was observed only when the HbA₁c level was over 6·8 %. The associations appeared to be greater when the quantile levels of HbA₁c were higher. The coefficient estimates were − 0·174 (95 % CI − 0·433, − 0·025) at the quantile of 0·60, − 0·200 (95 % CI − 0·306, − 0·008) at 0·70, − 0·221 (95 % CI − 0·426, − 0·117) at 0·80, and − 0·389 (95 % CI − 0·516, − 0·018) at 0·90. A similar pattern was observed for the associations of dietary glycaemic index (GI) value with HbA₁c levels. In conclusion, the present results indicate that the associations of insoluble dietary fibre intake and GI value with subsequent HbA₁c levels depend on glycaemic control status in Chinese diabetic patients. More studies are required to confirm our findings.
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