Effect of vitamin D deficiency on lipid composition and calcium transport in basolateral membrane vesicles from chick intestine
1997
Alisio, A. | Canas, F. | Bronia, D.H. de | Pereira, R. | Tolosa de Talamoni, N.
Vitamin D deficiency affects the lipid composition and Ca(2+) uptake of intestinal basolateral membranes from chick intestine. The increased cholesterol content causes an increase in the molar ratio cholesterol/phospholipid. Phospholipid classes remain unchanged, but the percentages of arachidonic acid from the major phospholipid fractions are increased. After 24 hours of oral of 2,000 IU Of cholecalciferol to vitamin D-deficient chicks, the cholesterol values do not change, but the amount of arachidonic acid returns to normal values. Ca(2+) uptake driven by ATP is diminished in vesicles from intestinal basolateral membranes of vitamin D-deficient chicks. Cholecalciferol treatment returns these values to the controls which might be due mainly to the increased number of Ca(2+) pump units. In conclusion, changes in lipid composition and in Ca2(+) pump caused by vitamin D deficiency seems to play a role in the decrease of vesicular Ca(2+) transport. A single dose of cholecalciferol restores only partially the lipid-protein changes produced by vitamin D deficiency.
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