Immunogenicity of a novel, bivalent, plant-based oral vaccine against hepatitis B and human immunodeficiency viruses
2006
Shchelkunov, Sergei N. | Salyaev, Rurik K. | Pozdnyakov, Sergei G. | Rekoslavskaya, Natalia I. | Nesterov, Andrei E. | Ryzhova, Tatiana S. | Sumtsova, Valentina M. | Pakova, Natalia V. | Mishutina, Uliana O. | Kopytina, Tatiana V. | Hammond, Rosemarie W.
A synthetic chimeric gene, TBI-HBS, encoding the immunogenic ENV and GAG epitopes of human immunodeficiency virus (HIV-1) and the surface protein antigen (HBsAg) of hepatitis B virus (HBV), was expressed in tomato plants. Tomato fruits containing the TBI-HBS antigen were fed to experimental mice and, on days 14 and 28 post-feeding, high levels of HIV- and HBV-specific antibodies were present in the serum and feces of the test animals. Intraperitoneal injection of a DNA vaccine directing synthesis of the same TBI-HBsAg antigen boosted the antibody response to HIV in the blood serum; however, it had no effect on the high level of antibodies produced to HBV.
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