Preparation of 6-aminoquinazolin-4(3H)-ones via direct SNAr on the quinazoline ring
2012
Barlaam, Bernard | Harris, Craig S. | Lecoq, Jonathan | Nguyen, Ha Thi Hoang
The preparation of 6-aminoquinazolin-4(3H)-ones requires the use of platinum–metal group catalysis on the corresponding C-6-iodo or 6-bromo precursors. Herein, we report to our knowledge the first successful SNAr reaction directly at the unactivated C-6 position of the quinazolin-4(3H)-one nucleus.
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