Dietary carotene and the risk of lung cancer
1982
A study (with an initial sample of 2107, mainly white men of European ancestry) was evaluated 19 years later for cumulative incidence of all cancers. Questionnaires from the 1546 survivors, hospital records, and death certificates, were evaluated to determine if there was a relationship between vitamin A intake and lung cancer. Bronchogenic carcinoma was diagnosed in 33 men; 14 of these individuals had carotene values below the 25th percentile, 25 were below the median and only 2 were above the 75th percentile. There was a significant inverse correlation between carotene index (by quartile) and incidence of lung cancer. It was confirmed that the carotene had a significant inverse association with the incidence of lung cancer after adjustment for duration of cigarette smoking, number of cigarettes smoked, retinol index, and age. However, much more evidence is needed to confirm the carotene hypothesis regarding lung cancer, such as evidence of antineoplastic activity of carotene in mamalian tumors. (kbc)
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