High-temperature continuous flow synthesis of 1,3,4-oxadiazoles via N-acylation of 5-substituted tetrazoles
2012
Reichart, Benedikt | Kappe, C Oliver
Applying continuous flow processing in a high-temperature/high-pressure regime (200–220°C, 11–14bar) 2,5-disubstituted-1,3,4-oxadiazoles are prepared in high yields within 5–10min residence time by treatment of 5-substituted-1H-tetrazoles with anhydrides or acid chlorides as electrophiles (Huisgen reaction).
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