Multicomponent Strategy to Pyrazolo[3,4-e]indolizine Derivatives under Microwave Irradiation
2015
Wang, Jian-Jun | Feng, Xian | Xun, Zhan | Shi, Da-Qing | Huang, Zhi-Bin
A simple and efficient one-pot construction of pyrazolo[3,4-e]indolizine derivatives via a diethylamine-catalyzed three-component domino reaction of arylglyoxals, cyclic 1,3-diones, and 5-aminopyrazoles under microwave irradiation is described. In this one-pot transformation, seven bonds and two new rings are efficiently formed. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional recrystallization or chromatography purification methods.
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