Effects of ENU dosage on mouse strains
2000
Justice, Monica J | Carpenter, Don A | Favor, Jack | Neuhauser-Klaus, Angelika | Hrabé de Angelis, Martin | Soewarto, Dian | Moser, Amy | Cordes, Sabine | Miller, Darla | Chapman, Verne | Weber, John S | Rinchik, Eugene M | Hunsicker, Patricia R | Russell, William L | Bode, Vernon C
The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F₁ hybrids to ENU. The results show that most F₁ hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.
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