Cell-mediated cytotoxicity and humoral immune response in ascorbic acid deficient guinea pigs
1979
Anthony, Luean E. | Kurahara, Carole G. | Taylor, Keith B.
Guinea pigs were divided into three dietary groups (ascorbic-acid deficient, pair-fed, and ad libitum control) to examine the effect of ascorbic acid deficiency on cell-mediated immunity and the primary humoral response. Using chicken erythrocytes as target cells, the cytotoxicity of spleen lymphoid cells from immunized ascorbic acid deficient guinea pigs was assessed by a 51-Cr release technique. Hemaglutinating antibody titers to chicken erythrocytes 2 weeks after immunization were comparable in all three groups. In vitro 51-Cr release from spleens of ascorbic acid deficient guinea pigs was significantly less than with spleen cells from pair-fed and ad libitum control guinea pigs. The percentage of splenic lymphoid cells that formed rosettes with rabbit erythrocytes, a T cell marker, was the same in all three groups. Ascorbic acid deficiency may reflect an impairment of T lymphocyte function in cell-mediated cytotoxicity or a change in number or function of another cell type.
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