Differential decrease of copper content and of copper binding to superoxide dismutase in liver, heart and brain of copper-deficient rats
1994
Rossi, L. | Ciriolo, M.R. | Marchese, E. | De Martino, A. | Giorgi, M. | Rotilio, G.
Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an apo-form of superoxide dismutase, which can be reactivated by addition of exogenous copper to tissue extracts. These results demonstrate in vivo that superoxide dismutase is post-translationally modulated by copper in higher vertebrates as previously found for yeast and mammalian cells in culture.
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