Bacterial Cellulose as a Supersoft Neural Interfacing Substrate
2018
Yang, Junchuan | Du, Mingde | Wang, Le | Li, Sixiang | Wang, Guorui | Yang, Xinglong | Zhang, Lijuan | Fang, Ying | Zheng, Wenfu | Yang, Guang | Jiang, Xingyu
Biocompatible neural interfaces hold great promise for treating neurological disorders and enhancing the mental and physical ability of human beings. Most of the currently available neural interfaces are made from rigid, dense inorganic materials that cause tissue damage. We present supersoft multichannel electrodes by depositing gold layers on thin bacterial cellulose (BC) (Au-BC electrodes). The Young’s modulus of BC (EBC = 120 kPa) is between those of the brain tissue (Ebᵣₐᵢₙ = 2.7–3.1 kPa) and the peripheral neural tissues (Eₚₑᵣᵢₚₕₑᵣₐₗ ₙₑᵣᵥₑ = 580–840 kPa). The bending stiffness of the Au-BC electrodes corresponds to 1/5200 of Au-polyimide electrodes with the same layout. Furthermore, the Au-BC electrodes are highly durable (conductivity >95% after 100 cycles of 180° bending). In vivo recording of brain electric activity demonstrates the great potential of the Au-BC electrodes for neural interfacing applications.
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