Palladium-Catalyzed β-Arylation of α-Keto Esters
2017
Zavesky, Blane P. | Bartlett, Samuel L. | Johnson, Jeffrey S.
A catalyst system derived from commercially available Pd₂(dba)₃ and PᵗBu₃ has been applied to the coupling of α-keto ester enolates and aryl bromides. The reaction provides access to an array of β-stereogenic α-keto esters. When the air-stable ligand precursor PᵗBu₃·HBF₄ is employed, the reaction can be carried out without use of a glovebox. The derived products are of broad interest given the prevalence of the α-keto acid substructure in biologically important molecules.
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