Clinical, biochemical and nutritional spectrum of zinc deficiency in human subjects: An update
1983
Prasad, Ananda S.
Clinical symptoms of zinc (Zn) deficiency, its diagnosis, and the role of Zn in human nutrition and metabolism are extensively reviewed. Since the recognition of the essentiality of dietary Zn in the early 1960s, much information has been developed concerning Zn nutriture. Zn deficiency has been found to be associated with a number of diseases (e.g., malabsorption syndrome; chronic renal disease; liver cirrhosis; sickle cell disease). Zinc is involved in many biochemical functions, including Zn metalloenzymes, microorganism cell cycle stops, and DNA (and protein) synthesis. Zn also appears to protect liver cells from carbon tetrachloride poisoning damage, suggesting its direct effect on free radicals. Its competition with cadmium and lead may be potentially useful in alleviating the toxic effects of these heavy elements in humans. (wz)
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