Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription
2009
Tavenet, Arounie | Suleau, Audrey | Dubreuil, Géraldine | Ferrari, Roberto | Ducrot, Cécile | Michaut, Magali | Aude, Jean-Christophe | Dieci, Giorgio | Lefebvre, Olivier | Conesa, Christine | Acker, Joël
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
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