Bone mineral content in postmenopausal women, calcium intake early in life, and estrogen therapy
1990
Hunt, I.F. | Murphy, N.J. | Clark, V.A. | Judd, H.L. | Cedars, M.I. | Browdy, B.L.
A cross-sectional study of the relationship of calcium intake and estrogen therapy (ET) to cortical bone mineral content/bone width (BMC/BW) was conducted in 129 postmenopausal "free-living" women in California. Diet was assessed by frequency questionnaire, ET by interview, and BMC by single-photon absorptiometry. Women with adequate ET (defined as greater than or equal to 0.625 mg conjugated equine estrogen/d for > 20 d/mo beginning within 3 y after menopause and continuing > 3 y) were compared to those who had not received ET. Calcium intakes early in life (15 to 30 y of age) were predictive of BMC/BW only in women with adequate ET. Calcium intakes later in life were not predictive regardless of ET. In women who had both adequate ET and early calcium intakes > 500 mg/d, BMC/BW could be expected to fall below the "fracture threshold" (0.58 g/cm2) about 17 y later than in all other subjects. Adequate early calcium intakes may contribute to bone formation and, since ET reduces bone loss, the 2 strategies combined may be more effective in maintaining BMC than either one alone.
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