Effects of chronic alcohol feeding on thiamin status: Biochemical and neurological correlates
1981
Shaw, Spencer | Gorkin, Brett David | Lieber, Charles S.
Chronic alcohol feeding had no effect on thiamin tissue content of rats fed liquid diets containing excess amounts of thiamin. For up to 6 months, rats were pair-fed diets which contained ethanol as 36% of total calories or identical diets with the same amount of calories substituted by carbohydrate. Avoidance learning behavior was impaired in an additional group of rats fed a control diet deficient in thiamin; learning was not impaired in animals fed either (thiamin-adequate) control or ethanol-containing diets. In similar experiments with baboons pair-fed diets containing ethanol as 50% of total calories or control diets for up to 3 years, chronic alcohol feeding also had no effect on blood thiamin concentration or urinary thiamin excretion. Thus, as long as the diet is nutritionally supplemented with thiamin, chronic alcohol feeding does not appear to impair thiamin status. However, diets which are low in thiamin may be adversely affected by alcohol.
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