Gastroesophageal Reflux Type and Number Correlate with Nutritional Patterns (P06-066-19)

The correlation of nutritional patterns with number and types of gastroesophageal refluxes is poorly studied yet. Aim: To assess the effect of actual nutrition of GERD patients on the number and type of gastroesophageal reflux detected with 24-hours esophageal pH-impedance. One hundred twenty-four GERD patients (54 men, age (M ± m): 46 ± 17.7 y.o., BMI 28.5 ± 0.6 kg/m²) and 41 healthy controls (8 men, age 42 ± 12.4 y.o., BMI 28.3 ± 1.3 kg/m²) were examined with the use of language-specific food frequency questionnaire and 24-hours esophageal pH-impedance (Ohmega, MMS; 2 pH, 6 impedance catheters, Unisensor). The correlation analysis between macro- and micronutrient consumption and the number of gastroesophageal refluxes (GER), their acidity and duration was performed (Statistica 10, StatSoft) Direct medium-strength correlation was found between esophageal acid exposure time and the energy value of the ration (Spearman rank R = 0.19, p < 0.05), and the amount of consumed fat (R = 0.2, p < 0.05). There was a direct correlation of the total number of GERs with the energy value of the ration (R = 0.35, p < 0.05), protein (R = 0.3, p < 0.05), fat (R = 0.33, p < 0.05), and alcohol consumption (R = 0.28, p < 0.05) and the inverse one with the dietary fiber consumption (R = −0.22). Significant direct correlation was found between the number of acid GERs and total energy value of the ration (R = 0.35, p < 0.05), consumption of fat (R = 0.32, p < 0.05), protein (R = 0.25, p < 0.05), carbohydrates (R = 0.24, p < 0.05) and alcohol (R = 0.24, p < 0.05). Number of weak-acid GERs showed direct correlation with the calories intake (R = 0.22, p < 0.05), fat (R = 0.21, p < 0.05), protein (R = 0.22, p < 0.05), alcohol (R = 0.23, p < 0.05) consumption, and the inverse one with the amount of dietary fiber intake (R = −0.24, p < 0.05). Number of high GERs correlated directly with the amount of fat (R = 0.3, p < 0.05), protein (R = 0.22, p < 0.05), alcohol (R = 0.25, p < 0.05) consumed, and inversely with the amount of dietary fiber (R = −0.25, p < 0.05) in the ration. Paired comparison of the correlation coefficients was performed, but didn't reveal any difference. High energy value, consumption of fat and alcohol showed direct medium-strength correlation with esophageal acid exposure and number of GERs. Dietary fiber consumption correlated inversely with total number, weak acid and high GERs. Federal research Center of Nutrition and Biotechnology, Russian science foundation.