Effect of soy phosphatidyl choline on the bioavailability and nutritional health benefits of resveratrol
2011
Mukherjee, Kakali | Vekaṭēṣ, Mu. | Venkatesh, P. | Saha, B.P. | Mukherjee, Pulok K.
Resveratrol has several nutritional health benefits including a cardioprotective effect. Although it has high oral absorption, but its rapid metabolism results in less systemic availability and restrict its efficacy. To overcome this, resveratrol complex with hydrogenated soy phosphatidyl choline (HSPC) was developed and its effect was evaluated on doxorubicin induced cardiotoxicity in rats. The cardioprotective activity of the resveratrol complex and free resveratrol (4 and 8mg/kg) were evaluated by measuring various antioxidants and cardio protective enzymes. The complex significantly restored the activity of SOD, catalase, LDH and creatine kinase with respect to doxorubicin treated group (P<0.05 and <0.01). Plasma concentration of resveratrol obtained from the complex was higher than pure resveratrol. This study highlighted on the improved bioavailability and cardio protective health benefit of resveratrol by HSPC due to its sustained delivery and potential antioxidant property.
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