Synthesis, mechanism of action, and QSAR of herbicidal 3-substituted-2-aryl-4,5,6,7-tetrahydroindazoles
1994
Lyga, J.W. | Patera, R.M. | Plummer, M.J. | Halling, B.P. | Yuhas, D.A.
A factorially designed set of 3-substituted 2-aryl-4,5,6,7-tetrahydroindazoles was synthesized and their herbicidal properties were evaluated using regression analysis. For optimal activity, the substituent at position 3 should be neither strongly hydrophobic nor hydrophilic and should have a small minimum radius. A study of the mechanism of action indicated that the tetrahydroindazoles are inhibitors of the enzyme protoporphyrinogen oxidase.
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