Di-tert-butyl Peroxide-Promoted α-Alkylation of α-Amino Carbonyl Compounds by Simple Alkanes
2014
Peng, Haibo | Yu, Jin-Tao | Jiang, Yan | Yang, Haitao | Cheng, Jiang
A di-tert butyl peroxide (DTBP)-promoted α-alkylation of α-amino carbonyl compounds by simple alkanes is developed, proceeding through dual sp³ C–H bonds cleavage. The reaction was applicable for α-amino ketones and α-amino esters, providing a facile pathway for the α-functionalization of these substrates. The radical pathway is involved in this transformation.
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