Occurrence of colchicine derivatives in plants of the genus Androcymbium
2003
Ellington, E. | Bastida, J. | Viladomat, F. | Simanek, V. | Codina, C.
Androcymbium gramineum plants were phytochemically investigated for alkaloids. Two major alkaloids, colchicine and demecolcine, were isolated from the whole plant, and 2-demethylcolchicine, 3-demethylcolchicine, N-formyl-N-deacetylcolchicine and colchifoline have also been identified by HPLC analysis. This is the first report of demecolcine in A. gramineum, and of colchifoline in the genus Androcymbium. In addition, seeds of Androcymbium gramineum, Androcymbium hierrense, Androcymbium palaestinum, Androcymbium psammophilum, Androcymbium rechingerii, and Androcymbium wyssianum were also investigated for their alkaloid content for the first time. All were found to contain colchicine and colchicoside.
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