Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration to ostriches
2005
Lucas, J.J de | Rodriguez, C. | Waxman, S. | González, F. | Uriarte, I. | San Andres, M.I.
The pharmacokinetics of marbofloxacin was investigated after intravenous (IV) and intramuscular (IM) administration, both at a dose rate of 5 mg/kg BW, in six clinically healthy domestic ostriches. Plasma concentrations of marbofloxacin was determined by a HPLC/UV method. The high volume of distribution (3.22 +/- 0.98 L/kg) suggests good tissue penetration. Marbofloxacin presented a high clearance value (2.19 +/- 0.27 L/kg h), explaining the low AUC values (2.32 +/- 0.30 microgram h/mL and 2.25 +/- 0.70 microgram h/mL, after IV and IM administration, respectively) and a short half life and mean residence time (t(1/2beta) = 1.47 +/- 0.31 h and 1.96 +/- 0.35 h; MRT = 1.46 +/- 0.02 h and 2.11 +/- 0.30 h, IV and IM, respectively). The absorption of marbofloxacin after IM administration was rapid and complete (C(max) = 1.13 +/- 0.29 microgram/mL; T(max) = 0.36 +/- 0.071 h; MAT = 0.66 +/- 0.22 h and F (%) = 95.03 +/- 16.89).
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