Synthesis and pharmacokinetic characterization of a pH-sensitive polyethylene glycol ginsenoside CK (PEG-CK) conjugate
2014
Mathiyalagan, Ramya | Subramaniyam, Sathiyamoorthy | Kim, Yeon Ju | Natarajan, Sathishkumar | Min, Jin Woo | Kim, Se Young | Yang, Deok Chun
The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.
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