Lycopene induces insulin signaling and alleviates fibrosis in experimental model of non-alcoholic fatty liver disease in rats
2020
Saeed, Noha M. | Mansour, Ahmed M. | Allam, Shady
Lycopene (lyc) supplementation was shown to efficiently prevent multiple hepatic injuries. This study was assembled to examine lyc protective effects against non-alcoholic fatty liver disease (NAFLD) experimentally-induced in rats.The experiment was completed in eight weeks. Rats were indiscriminately distributed into four main groups: the control group and the high fat diet (HFD) fed group, received 1 mL/kg corn oil orally 3 times per week. Lyc only-treated group and HFD/lyc fed group, received 4 mg/kg of lyc orally 3 times per week.Lyc significantly renovated liver enzymes and alleviated histopathological abrasions induced by HFD. Moreover, lyc significantly enhanced insulin receptor substrate 2 (IRS 2) expression by 25 % and ameliorated oxidative stress injury through restoring GSH level by 218 % and Nrf 2 expression by 56 %. Additionally, lyc significantly reduced pro-inflammatory cytokines production; interleukin-6; IL-6 and tumor necrosis factor-alpha; TNF-α by 52 % and 57 % respectively, and inhibited nuclear factor-κB (NF-κB) by 52 %. Finally, lyc significantly reduced transforming growth factor-β (TGF-β) expression by 52 % and α-smooth muscle actin (α-SMA) expression by 53 % as well as collagen accumulation.According to these findings, lyc may be recommended as a promising dietary agent in the management of NAFLD.
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