Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia
2014
Li, Yaqian | Liu, Wei | Liu, Fei | Zeng, Yang | Zuo, Simin | Feng, Siyu | Qi, Chunxiao | Wang, Bingjie | Yan, Xiaojun | Khademhosseini, Ali | Bai, Jing | Du, Yanan
Significance Optimal cell delivery strategies are in urgent need to enhance the specificity, efficacy, and reproducibility of cell therapy leading to minimized cell dosage and side effects. Here, we addressed this unmet need by developing injectable 3D microscale cellular niches (microniches) based on biocompatible and biodegradable gelatin microcryogels. Dramatic improvement in cell retention, survival, and therapeutic effects enabled by the primed 3D microniches was demonstrated in treatment of critical limb ischemia (CLI) in mouse models compared with the free cell-based therapy. To the best of our knowledge, this is the first convincing demonstration of injectable and primed cell delivery strategy realizing superior therapeutic efficacy with the lowest cell dosage for treating CLI in mouse model.
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