Antignawing Factor Derived from Cinnamomum cassia Bark Against Mice
1999
Yi, Hŭi-gwŏn | Lee, Hoi-Seon | Ahn, Young-Joon
The antignawing activity of cinnamomi cortex (the dried bark of Cinnamomum cassia) derived materials against laboratory-reared mice was evaluated using a wire-dipping method. The biologically active component of C. cassia bark was characterized by spectral analysis as cinnamaldehyde. The antignawing activity of the compound was compared with that of four commercially available compounds: cinnamyl alcohol, trans-cinnamic acid, eugenol, and salicylaldehyde. Cinnamaldehyde and cinnamyl alcohol exhibited potent repellent activity, whereas little or no activity was produced from salicylaldehyde. Moderate activity was observed in trans-cinnamic acid and eugenol. Cinnamaldehyde and cinnamyl alcohol exhibited potent and moderate repellent activity at 5 and 2.5% solutions, respectively, of these compounds in ethanol. Little or no activity was observed in 1% solution. As a naturally occurring repellent, cinnamaldehyde and cinnamyl alcohol could be useful as a new preventive agent against various kinds of damage caused by rodents.
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