Efficient synthesis, and antitumor and antioxidant activities of polyhydroxybenzophenone
2021
Zhou, Bei-Dou | Li, Jia-Li | Ruan, Zhi-Peng | Xu, Gui-Fen | Fang, Yuan-Yuan | Lin, Jian | Zhang, Xiao-Ling | Hu, Dong-Bao
Five polyhydroxybenzophenones were synthesized, then their antitumor and antioxidant activities were evaluated. Compounds 1–3 and 5 exhibited obvious antitumor activity. Among them, compounds 1 and 2 exhibited stronger cytotoxicity against hepatocarcinoma SMMC-7721 cells than cisplatin, with half maximal inhibitory concentrations (IC₅₀) of approximately 3.86 and 5.32 μM, respectively. Compounds 1, 2, and 3 exhibited stronger antioxidant activity than trolox, with IC₅₀ values of 11.15, 10.15, and 8.91 μM, respectively, and the antioxidant mechanism and strength of all compounds were further verified using computational chemistry. These results demonstrated that compounds 1–3 and 5 were very promising leads for further structural modification.
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