Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF₄)
2021
Trofymchuk, Serhii | Bugera, Maksym | Klipkov, Anton A. | Ahunovych, Volodymyr | Razhyk, Bohdan | Semenov, Sergey | Boretskyi, Andrii | Tarasenko, Karen | Mykhailiuk, Pavel K.
A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF₄). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
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