The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum
2012
You, Hong | Gobert, Geoffrey N. | Duke, Mary G. | Zhang, Wenbao | Li, Yuesheng | Jones, Malcolm K. | McManus, Donald P.
Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S.japonicum insulin receptor 2 (SjLD2) in three independent murine vaccine/challenge trials. Compared with controls, vaccination of mice with SjLD2 resulted in a significant reduction in faecal eggs, the stunting of adult worms and a reduction in liver granuloma density in all three trials. Furthermore, in the final trial, in which mature intestinal eggs were also quantified, there was a reduction in their number. These results suggest that development of a vaccine based on rSjLD2 for preventing transmission of zoonotic schistosomiasis is feasible.
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