Hydroxyurea as an inhibitor of hepatitis C virus RNA replication
2010
Nozaki, Akito | Morimoto, Manabu | Kondō, Masaaki | Oshima, Takashi | Numata, Kazushi | Fujisawa, Shin | Kaneko, Takeshi | Miyajima, Eiji | Morita, Satoshi | Mori, Kyoko | Ikeda, Masanori | Kato, Nobuyuki | Tanaka, Katsuaki
Hepatitis C virus (HCV) is the main causative agent of chronic liver disease, which may develop into liver cirrhosis and hepatocellular carcinoma. By using a recently developed reporter assay system in which genome-length HCV RNA replicates efficiently, we found that hydroxyurea (HU), a DNA synthesis inhibitor, inhibited HCV RNA replication. Moreover, we demonstrated that the anti-HCV activity of the combination of IFN-alpha and HU was higher than that of IFN-alpha alone. These results suggest that HU may be an effective anti-HCV reagent that can be used not only singly but also in combination with IFN-alpha to treat chronic hepatitis C.
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