Chemical characterization of Artemisia mesatlantica essential oils and evaluation of their anticandidosic potential | Caractérisation chimique des huiles essentielles d’Artemisia mesatlantica et évaluation de leur potentiel anticandidosique
2017
Sekkat, Z.L. | Rouani, M. | Ghazi, S. | Il Idrissi, A. | Arahou, M. | Hassikou, R.
The present work has a twofold purpose, the first is to valorize an endemic species of Morocco, which is widely used in traditional medicine and the second to suggest an alternative to synthetic anti-candida products, especially against Candida albicans. It’s about the blue wormwood (Artemisia mesatlantica M.) which is rarely discussed in the literature.In order to do this, the essential oil from a recent technical by microwave (MO) and another traditional by steam distillation (EVE), were analyzed by gas chromatography coupled with mass spectrometry. The anti-candida tests of three essential oils extracted by microwave (MO), hydrodistillation (H) and stream distillation (E.V.E), were performed on five reference strains. Five-fold dilutions were prepared ranging from 50% (v/v) to 3.12% (v/v). The minimum inhibitory concentrations were determined by microdilution.The chemical composition of oils shows that the main components are: β-thujone for both techniques EVE (62,05%) and MO (51,81%), followed by camphor (14.39%) for MO and α- thujone (4.68%) for EVE. The best potential is obtained in the case of the essential oil extracted by microwave. Reference synthetic products were also tested with approved doses and are generally ineffective
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