A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants
2022
Jaspers, Maarten | Roelofs, Timo P. | Janssen, Pauline H.M. | Meier, Robin | Dickhoff, Bastiaan H.J.
Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the inherently continuous nature of the process. A common problem of dry granulation, however, is the loss of compactibility of the granules compared to the ungranulated powders. Here we show a novel approach to minimize the loss of compactibility during dry granulation. The intra-granular addition of superdisintegrant reduces the loss of compactibility of anhydrous lactose-based granules produced via roller compaction. This effect is explained by a reduced hardness of the granules, which promotes granule fragmentation upon tablet compression. This higher degree of fragmentation increases the lactose surface available for bonding, thereby improving tablet strength. The results presented here show how intra-granular superdisintegrants can be used to minimize the loss of compactibility of a dry granulation formulation.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por National Agricultural Library