Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors
2012
Pastor, Joaquin | Oyarzabal, Julen | Saluste, Gustavo | Alvarez, Rosa María | Rivero, Virginia | Ramos, Francisco | Cendón, Elena | Blanco-Aparicio, Carmen | Ajenjo, Nuria | Cebriá, Antonio | Albarrán, M.I. | Cebrián, David | Corrionero, Ana | Fominaya, Jesús | Montoya, Guillermo | Mazzorana, Marco
PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described.
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