How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Apoptosis
2023
Zheng, Wanglong | Liu, Anjing | Xia, Nengwen | Chen, Nanhua | Meurens, François | Zhu, Jianzhong | Yangzhou University | Joint International Research Laboratory of Agriculture and Agri-Product Safety ; Partenaires INRAE | Comparative Medicine Research Institute ; Yangzhou University | Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses | Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR) ; École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | University of Saskatchewan [Saskatoon, Canada] (U of S) | The work was partly supported by the National Natural Science Foundation of China (32202818; 32172867; 31872450), the 111 Project D18007, and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
International audience
Mostrar más [+] Menos [-]Inglés. The cGAS–STING signaling axis can be activated by cytosolic DNA, including both non-self DNA and self DNA. This axis is used by the innate immune system to monitor invading pathogens and/or damage. Increasing evidence has suggested that the cGAS-STING pathway not only facilitates inflammatory responses and the production of type I interferons (IFN), but also activates other cellular processes, such as apoptosis. Recently, many studies have focused on analyzing the mechanisms of apoptosis induced by the cGAS-STING pathway and their consequences. This review gives a detailed account of the interplay between the cGAS-STING pathway and apoptosis. The cGAS-STING pathway can induce apoptosis through ER stress, NLRP3, NF-κB, IRF3, and IFN signals. Conversely, apoptosis can feed back to regulate the cGAS-STING pathway, suppressing it via the activation of caspases or promoting it via mitochondrial DNA (mtDNA) release. Apoptosis mediated by the cGAS-STING pathway plays crucial roles in balancing innate immune responses, resisting infections, and limiting tumor growth.
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