Drugs in Focus: Domperidone
2023
Puoti, Maria Giovanna | Assa, Amit | Benninga, Marc | Broekaert, Ilse Julia | Carpi, Francisco Javier Martin | Deganello Saccomani, Marco | Dolinsek, Jernej | Homan, Matjaz | Mas, Emmanuel | Miele, Erasmo | Tzivinikos, Christos | Thomson, Mike | Borrelli, Osvaldo | Great Ormond Street Hospital for Children [London] (GOSH) | The Hebrew University of Jerusalem (HUJ) | Universität zu Köln = University of Cologne | Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona (UAB) | University of Maribor | University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL) | Institut de Recherche en Santé Digestive (IRSD) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | "Federico II" University of Naples Medical School | Al Jalila Children's Specialty Hospital
International audience
Mostrar más [+] Menos [-]Inglés. Domperidone is a peripheral dopamine-2 receptor antagonist with prokinetic and antiemetic properties. Its prokinetic effects are mainly manifest in the upper gastrointestinal (GI) tract. Currently its use is restricted to relief of nausea and vomiting in children older than 12 years for a short period of time. However, among (pediatric) gastroenterologists, domperidone is also used outside its authorized indication (“off label”) for treatment of symptoms associated with gastro-esophageal reflux disease, dyspepsia, and gastroparesis. Little is known about its efficacy in the treatment of GI motility disorders in children and controversial data have emerged in the pediatric literature. As its use is off label, appropriate knowledge of its efficacy is helpful to support an “off label/on evidence” prescription. Based on this, the purpose of this review is to summarize all evidence on the efficacy of domperidone for the treatment of GI disorders in infants and children and to report an overview of its pharmacological properties and safety profile.
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Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique