Candida albicans biofilms: building a heterogeneous, drug-tolerant environment.
2013
Bonhomme, Julie | D'Enfert, Christophe | Université de Caen Normandie (UNICAEN) ; Normandie Université (NU) | Biologie et Pathogénicité fongiques (BPF) ; Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP) | We are grateful to members of the Unite´ Biologie et Pathogénicité Fongiques for lively and fruitful discussions on the topics of this review. CdE is supported by grants of the Agence Nationale de la Recherche (KANJI, ANR-08-MIE-033-01; ERA-Net Pathogenomics CANDICOL ANR-10-01), the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence ‘‘Integrative Biology of Emerging Infectious Diseases’’ (ANR-10-LABX-62-IBEID) and the European Commission (FINSysB, PITN-GA-2008-214004). JB was the recipient of a fellowship of the Fondation pour la Recherche Medicale (DEA20080713005). | ANR-08-MIEN-0033,KANJI,Colonisation et invasion de la muqueuse digestive par le champignon pathogène de l'homme Candida albicans(2008) | ANR-10-PATH-0008,CANDICOL(2010) | ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010) | European Project: 214004,PEOPLE,FP7-PEOPLE-2007-1-1-ITN,FINSYSB(2008)
International audience
Mostrar más [+] Menos [-]Inglés. Fungi are able to form biofilms on medical implants, causing serious infections. A better understanding of fungal biofilm formation is necessary to develop tools for detection or prevention and to identify new antifungal strategies. This review explores recent advances in the characterization at the molecular level of fungal biofilms, especially those formed by the yeast Candida albicans: the identification of complex transcriptional networks that control their formation; the pivotal role of the extracellular matrix in biofilm antifungal tolerance; and the knowledge gained on the physiology of biofilm cells and heterogeneity within these communities. These findings may help develop new, targeted therapeutic strategies.
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