Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model
2021
Jollet, Maxence | Nay, Kevin | Chopard, Angèle | Bareille, Marie-Pierre | Beck, Arnaud | Ollendorff, Vincent | Vernus, Barbara | Bonnieu, Anne | Mariadassou, Mahendra | Rué, Olivier | Derbré, Frédéric | Goustard, Bénédicte | Koechlin-Ramonatxo, Christelle | Dynamique Musculaire et Métabolisme (DMEM) ; Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Laboratoire Mouvement Sport Santé (M2S) ; Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique) | Institut de Médecine et de Physiologie Spatiales (MEDES-IMPS) ; Centre Hospitalier Universitaire d'Angers (CHU Angers) ; PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Université de Bordeaux (UB)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Université Jean Monnet - Saint-Étienne (UJM)-Université de Tours (UT)-Université de Clermont-Ferrand-Centre National d'Études Spatiales [Toulouse] (CNES) | Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Université de Rennes (UR) | Centre National D'etudes Spatiales 4800000997, 4800001079 | ANR-11-INBS-0013,IFB (ex Renabi-IFB),Institut français de bioinformatique(2011)
International audience
Mostrar más [+] Menos [-]Inglés. Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles are widespread and associated with negative health and socio-economic impacts. The study aim was to determine the effect of Dry Immersion (DI), a severe hypoactivity model, on the human gut microbiota composition. Stool samples were collected from 14 healthy men before and after 5 days of DI to determine the gut microbiota taxonomic profiles by 16S metagenomic sequencing in strictly controlled dietary conditions. The α and β diversities indices were unchanged. However, the operational taxonomic units associated with the Clostridiales order and the Lachnospiraceae family, belonging to the Firmicutes phylum, were significantly increased after DI. Propionate, a short-chain fatty acid metabolized by skeletal muscle, was significantly reduced in post-DI stool samples. The finding that intestine bacteria are sensitive to hypoactivity raises questions about their impact and role in chronic sedentary lifestyles.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique