The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus
2021
Schwochow, Doreen | Bornelöv, Susanne | Jiang, Tingxing | Li, Jingyi | Gourichon, David | Bed’hom, Bertrand | Dorshorst, Ben | Chuong, Cheng‐ming | Tixier-Boichard, Michèle | Andersson, Leif | Uppsala University | Génétique Animale et Biologie Intégrative (GABI) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Science for Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology ; Uppsala University | University of Southern California (USC) | Department of Animal and Poultry Science, Virginia Tech ; Partenaires INRAE | Texas A&M University [College Station] | Unité Expérimentale Avicole de Tours (UE PEAT) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Institut de Systématique, Evolution, Biodiversité (ISYEB) ; Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) | Rådsprofessur/VetenskapsrådetKAW scholar/Knut och Alice Wallenbergs StiftelseAR060306/Foundation for the National Institutes of Health
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Mostrar más [+] Menos [-]Inglés. Color patterns within individual feathers are common in birds but little is known about the genetic mechanisms causing such patterns. Here, we investigate the genetic basis for autosomal barring in chicken, a horizontal striping pattern on individual feathers. Using an informative backcross, we demonstrate that the MC1R locus is strongly associated with this phenotype. A deletion at SOX10, underlying the dark brown phenotype on its own, affects the manifestation of the barring pattern. The coding variant L133Q in MC1R is the most likely causal mutation for autosomal barring in this pedigree. Furthermore, a genetic screen across six different breeds showing different patterning phenotypes revealed that the most striking shared characteristics among these breeds were that they all carried the MC1R alleles Birchen or brown. Our data suggest that the presence of activating MC1R mutations enhancing pigment synthesis is an important mechanism underlying pigmentation patterns on individual feathers in chicken. We propose that MC1R and its antagonist ASIP play a critical role for determining within-feather pigmentation patterns in birds by acting as activator and inhibitor possibly in a Turing reaction-diffusion model.
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