Emodepside and SL0-1 potassium channels: a review
2012
Martin, R.J. | Buxton, S.K. | Neveu, Cédric | Charvet, Claude | Robertson, A.P. | Iowa State University (ISU) | Infectiologie et Santé Publique (UMR ISP) ; Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT) | National Institute of Allergy and Infectious Diseases NIH grant 2R56AI047194-11
International audience
Mostrar más [+] Menos [-]Inglés. Nematode parasites infect humans and domestic animals; treatment and prophylaxis require anthelmintic drugs because vaccination and sanitation is limited. Emodepside is a more recently introduced cyclooctadepsipeptide drug that has actions against GI nematodes, lungworm, and microfilaria. It has a novel mode of action which breaks resistance to the classical anthelmintics (benzimidazoles, macrocyclic lactones and cholinergic agonists). Here we review studies on its mode of action which suggest that it acts to inhibit neuronal and muscle activity of nematodes by increasing the opening of calcium-activated potassium (SLO-1) channels.
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