Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats
2017
Beaumont, Martin | Jaoui, Daphné | Douard, Véronique | Mat, Damien | Koeth, Fanny | Goustard, Bénédicte | Mayeur, Camille | Mondot, Stanislas | Hovaghimian, Anais | Le Feunteun, Steven | Chaumontet, Catherine, C. | Davila, Anne-Marie | Tomé, Daniel, D. | Souchon, Isabelle | Michon, Camille | Fromentin, Gilles | Blachier, Francois, F. | Leclerc, Marion | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Génie et Microbiologie des Procédés Alimentaires (GMPA) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Ingénierie, Procédés, Aliments (GENIAL) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | ANR-11-IDEX-0003,IPS,Idex Paris-Saclay(2011)
International audience
Mostrar más [+] Menos [-]Inglés. Scope: Few studies have evaluated in vivo the impact of food structure on digestion, absorptionof nutrients and on microbiota composition and metabolism. In this study we evaluated in ratthe impact of two structures of protein emulsion in food on gut microbiota, luminal contentcomposition, and intestinal characteristics.Methods and results: Rats received for 3 weeks two diets of identical composition but basedon lipid-protein matrices of liquid fine (LFE) or gelled coarse (GCE) emulsion. LFE diet led tohigher abundance, when compared to the GCE, of Lactobacillaceae (Lactobacillus reuteri) in theileum, higher -diversity of the caecum mucus-associated bacteria. In contrast, the LFE diet ledto a decrease in Akkermansia municiphila in the caecum. This coincided with heavier caecumcontent and higher amount of isovalerate in the LFE group. LFE diet induced an increasedexpression of (i) amino acid transporters in the ileum (ii) glucagon in the caecum, togetherwith an elevated level of GLP-1 in portal plasma. However, these intestinal effects were notassociated with modification of food intake or body weight gain.Conclusion: Overall, the structure of protein emulsion in food affects the expression of aminoacid transporters and gut peptides concomitantly with modification of the gut microbiotacomposition and activity. Our data suggest that these effects of the emulsion structure are theresult of a modification of protein digestion properties.
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