Study of single nucleotide polymorphism in the encoding exons of the AGT gene of an arterial hypertension patient from Azerbaijan

Abaszade, Zumrud; Gasımov, Karim; Shahmuradov, Ilham

Study of single nucleotide polymorphism in the encoding exons of the AGT gene of an arterial hypertension patient from Azerbaijan

2024

Abaszade, Zumrud | Gasımov, Karim | Shahmuradov, Ilham

Arterial hypertension, which affects 20-30% of the world's population, is one of the main causes of cardiovascular disease. According to existing ideas, arterial hypertension is caused by genetic and non-genetic reasons, however, in most cases (more than 90%), the specific cause (s) of this complication in essential hypertension is unknown. It is believed that blood pressure is under the control of numerous genes. One such gene is the AGT gene, which encodes the angiotensinogen/angiotensin protein hormone. To date, a total of 4129 SNPs for the AGT gene have been annotated in the dbSNP database https://www.ncbi.nlm.nih.gov/snp/?term=AGT). In this study, the nucleotide sequences of the 3rd, 4th, 5th and 6th coding exons of the AGT gene in a sample of Azerbaijani patients living in Azerbaijan diagnosed with high arterial hypertension were read and compared with the corresponding reference sequences. It was found that there are 8 mutations in these exons, and all of them have been annotated in dbSNP resources. The results of studying the possible functional role of these mutations are interpreted below.

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