Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease
2020
Pienar, Corina | Benninga, Marc A. | Broekaert, Ilse J. | Dolinsek, Jernej | Mas, Emmanuel | Miele, Erasmo | Orel, Rok | Ribes-Koninckx, Carmen | Thomassen, Rut-Anne | Thomson, Mike | Tzivinikos, Christos | Thapar, Nikhil | Victor Babeş University of Medicine and Pharmacy (UMFT) | Emma Children’s Hospital Academic Medical Centre | University Hospital of Cologne | University medical centre Maribor (UKC Maribor) | Institut de Recherche en Santé Digestive (IRSD) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | University of Naples Federico II = Università degli studi di Napoli Federico II | University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL) | Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe | Oslo University Hospital [Oslo] | NHS Foundation Trust | Al Jalila Children's Specialty Hospital | UCL Great Ormond Street Institute of Child Health [London, UK] | Great Ormond Street Hospital ; Partenaires INRAE | Queensland Children's Hospital (QCH)
International audience
Mostrar más [+] Menos [-]Inglés. Acute diarrhoea is a leading cause of morbidity and mortality in the paediatric population. Racecadotril is an antisecretory drug recommended as an adjuvant anti-diarrhoeal treatment.In the small bowel, the enzyme neutral endopeptidase (NEP) inhibits the action of enkephalins, which prevent water and electrolyte hypersecretion. By inhibiting NEP, racecadotril allows enkephalins to exhibit their antisecretory effects. Consequently, racecadotril reduces the secretion of water and electrolytes in the small intestine, without having an effect on intestinal motility. No serious adverse events related to racecadotril have been reported.Racecadotril has proven its efficacy as an adjuvant anti-diarrhoeal drug with a good safety profile. Its addition to oral rehydration solution (ORS) appears clinically beneficial and potentially leads to health care savings.
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Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique
