Segregation of the InDel Mutation in IRF2BP2 Discriminating Fleece Type in North African and Iranian Sheep Breeds KEY WORDS association | Segregation of the InDel Mutation in IRF2BP2 Discriminating Fleece Type in North African and Iranian Sheep Breeds KEY WORDS association: The InDel Mutation Fleece Type in Sheep
2024
Belharfi, Fatima Zahra | Kdidi, Samia | Tabet Aoul, Nacera | Ameur, Abdelkader Ameur | Djaout, Amal | Hammadi, Mohamed | Sarry, Julien | Woloszyn, Florent | Fabre, Stéphane | Talebi, Reza | Khorchani, Touhami | Yahyaoui, Mohamed Habib | Gaouar, Semir Bechir Suheil | Université de Tlemcen = University of Tlemcen | Université de Gabès = University of Gabes | Institut des Régions Arides (IRA) | Université d'Oran 1 Ahmed Ben Bella [Oran] | Génétique Physiologie et Systèmes d'Elevage (GenPhySE) ; Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Agricultural Research, Education and Extension Organisation (AREEO)
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Mostrar más [+] Menos [-]Inglés. In sheep, the woolly or hairy fleece type shows variation within and between breeds and populations. Recently, the woolly allele was shown to result from the insertion of an antisens retrogene into the 3’UTR of the ovine IRF2BP2 gene. The purpose of this study was to examine this InDel polymorphism within the IRF2BP2 gene using a specific PCR genotyping in 17 North African (Algeria and Tunisia) and Iranian sheep breeds showing various fleece types. The genotyping of the overall animals (n=908) showed the segregation of the two alleles insertion (I) and deletion (D), and the three genotypes (II, ID and DD) with vari-ous frequencies. Ouled Djellal, Rembi and Tâadmit known as woolly breeds had 100%, 94% and 94% of II homozygous animals, respectively. In contrast, Ifilène and Sidaou known as hairy breeds had 100% and 99% of DD homozygous animals. Other breeds showed the segregation of the I allele with a frequency from 3% to 91%. An association analysis, carried out only for the Algerian sheep breeds, revealed that this polymorphism was significantly associated with the fleece type trait (P<0.05). Thus, the current work meets previous results to further confirm the genetic effect of the insertion occurring into the 3′ UTR of the IRF2BP2 gene on the fleece type trait of sheep breeds.
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