Chicory roots for prebiotics and appetite regulation: A pilot study in mice
2018
Foure, Marion | Dugardin, Camille | Foligne, Benoit | Hance, Philippe | Cadalen, Thierry | Delcourt, Abigaël | Taminiau, Bernard | Daube, Georges | Ravallec, Rozenn | Cudennec, Benoit | Hilbert, Jean-Louis | Lucau-Danila, Anca | Institut Charles Viollette (ICV) - EA 7394 (ICV) ; Université d'Artois (UA)-Institut National de la Recherche Agronomique (INRA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille | Centre Hospitalier Régional Universitaire [CHU Lille] (CHRU Lille) | Lille Inflammation Research International Center - U 995 (LIRIC) ; Institut Pasteur de Lille ; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [CHU Lille] (CHRU Lille) | Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich (ULiège) | University of Lille; European Union; French Region of Hauts-de-France
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Mostrar más [+] Menos [-]Inglés. The objectives of this work are to address the prebiotic effects of chicory (Cichorium intybus) together with its possible role in appetite control. We compared nine chicory genotypes in order to determine if variations in the content of metabolites in the roasted roots would lead to modifications in release of satiety hormones and in composition of gut microbiota. To this aim, a 5-week dietary-intervention study was achieved using mice fed with distinct chicory-based preparations. A 16S rRNA gene-based metagenetic analysis of fecal microbiota was performed. In vitro gastrointestinal digestions were performed in order to study the effect of chicory intestinal digests on gut hormone regulation in enteroendocrine cells. Firmicutes/ Bacteroidetes ratio and gut bacterial groups, such as Alloprevotella, Blautia, Alistipes, and Oscillibacter, were found to be modulated by chicory. On the other hand, CCK and GLP-1 satiety hormones were demonstrated to be significantly increased by chicory in vitro.
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