Replication mechanisms of circular ssDNA plant viruses and their potential implication in viral gene expression regulation
2023
Bonnamy, Mélia | Blanc, Stéphane | Michalakis, Yannis | Plant Health Institute of Montpellier (UMR PHIM) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier ; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM) | Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC) ; Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [Occitanie])-Université de Montpellier (UM) | ANR-18-CE92-0028,Nanovirus,Aspects moléculaires et cellulaires du cycle de vie des virus multipartites: les nanovirus(2018) | ANR-16-IDEX-0006,MUSE,MUSE(2016)
International audience
Mostrar más [+] Menos [-]Inglés. The replication of members of the two circular single-stranded DNA (ssDNA) virus families Geminiviridae and Nanoviridae , the only ssDNA viruses infecting plants, is believed to be processed by rolling-circle replication (RCR) and recombination-dependent replication (RDR) mechanisms. RCR is a ubiquitous replication mode for circular ssDNA viruses and involves a virus-encoded Replication-associated protein (Rep) which fulfills multiple functions in the replication mechanism. Two key genomic elements have been identified for RCR in Geminiviridae and Nanoviridae : (i) short iterative sequences called iterons which determine the specific recognition of the viral DNA by the Rep and (ii) a sequence enabling the formation of a stem-loop structure which contains a conserved motif and constitutes the origin of replication. In addition, studies in Geminiviridae provided evidence for a second replication mode, RDR, which has also been documented in some double-stranded DNA viruses. Here, we provide a synthesis of the current understanding of the two presumed replication modes of Geminiviridae and Nanoviridae , and we identify knowledge gaps and discuss the possibility that these replication mechanisms could regulate viral gene expression through modulation of gene copy number.
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Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique