Gαi proteins are indispensable for hearing
2018
Beer-Hammer, Sandra | Lee, Sze Chim | Mauriac, Stephanie A. | Leiss, Veronika | Groh, Isabel A. M. | Novakovic, Ana | Piekorz, Roland P. | Bucher, Kirsten | Chen, Chengfang | Ni, Kun | Singer, Wibke | Harasztosi, Csaba | Schimmang, Thomas | Zimmermann, Ulrike | Pfeffer, Klaus | Birnbaumer, Lutz | Forge, Andrew | Montcouquiol, Mireille | Knipper, Marlies | Nürnberg, Bernd | Rüttiger, Lukas
Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear.
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