Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae)
2019
Lima-Barbero, José Francisco | Sánchez, Marta Sánchez | Cabezas-Cruz, Alejandro | Mateos-Hernandez, Lourdes | Contreras, Marinela | de Mera, Isabel | Villar, Margarita | de La Fuente, Jose | SaBio (CSIC-UCLM-JCCM) ; Instituto de Investigación en Recursos Cinegéticos (IREC) | Sabiotec ; Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM) | Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR) ; École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) | Department of Veterinary Pathobiology, Center for Veterinary Health Sciences ; Oklahoma State University [Stillwater] (OSU) | Consejeria de Educacion, Cultura y Deportes, JCCM, Spain CCM17-PIC-036 (SBPLY/17/180501/000185)Doctorado Industrial from Ministerio de Ciencia, Innovacion y Universidades, Spain DI-14-06917Sabiotec S.A., Spain Universidad de Castilla La Mancha, Spain
International audience
Mostrar más [+] Menos [-]Inglés. Blood-feeding ectoparasites constitute a growing burden for human and animal health, and animal production worldwide. In particular, mites (Acari: Gamasida) of the genera Dermanyssus (Dermanyssidae) and Ornithonyssus (Macronyssidae) infest birds and cause gamasoidosis in humans. The tropical fowl mite, Ornithonyssus bursa, is commonly found in tropical and subtropical countries but rarely reported in Europe. In this research we characterized the first two cases in Spain of clinical gamasoidosis diagnosed in patients infested with O. bursa, and investigated the IgE, IgM and IgG antibody response to mite proteins and the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) involved in the tick-bite associated alpha-Gal syndrome (AGS). The results suggested that O. bursa is establishing across Mediterranean countries, and may increase the risk for gamasoidosis. The immune antibody response to mite proteins was higher for IgM and similar for IgE and IgG antibodies between patients and non-allergic control individuals exposed to mite or tick bites. The anti-α-Gal antibody levels were similar between patients and controls, a result supported by the absence of this carbohydrate in mites. These results suggested that mite bites do not correlate with antibody response to acarine proteins or α-Gal, and are not associated with the AGS.
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Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Institut national de la recherche agronomique