Lactobacillus fermentum PS150 showed psychotropic properties by altering serotonergic pathway during stress
2019
Liu, Y.W. | Ong, J.S. | Gan, C.Y. | Khoo, B.Y. | Yahaya, S. | Choi, S.B. | Low, W.Y. | Tsai, Y.C. | Liong, M.T.
In order to investigate novel probiotics for brain health improvement, the psychotropic potential of Lactobacillus fermentum PS150 (PS150) was evaluated using a 4-week chronic mild stress (CMS) model in rats. Rats fed with PS150 showed less anxious and depressive behaviour in EPM, OFT and FST compared with negative control rats (P < 0.05). Rats in PS150 group also showed less cognitive deficits as evaluated by MWM and NOR tests compared with negative control rats (P < 0.05). PS150 reversed the decrease of serotonin, elevation of IDO and ameliorated brain degeneration in the rat brain induced by CMS. Lowered interferon-γ gene expression and corticosterone levels in brain and plasma were observed in PS150 group compared with the negative control (P < 0.05). Taken together, PS150 prevented stress-mediated reduction of serotonin and neurodegeneration in the rat brain and helped stressed rats achieved more normal behaviour demonstrating the psychotropic potential of PS150 via the gut-brain axis.
Mostrar más [+] Menos [-]Yen-Wenn Liu, Jia Sin Ong, Chee Yuen Gan, Boon Yin Khoo, Sawibah Yahaya, Sy Bing Choi, Wai Yee Low, Ying-Chieh Tsai, Min Tze Liong
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